Galen Pharmacology Exam 1 Practice Test 2026 – Comprehensive All-in-One Guide for Exam Success!

The question is testing recognition of antidepressant classes. Tricyclic antidepressants are older drugs known for their three-ring chemical structure and their mechanism of blocking reuptake of norepinephrine and serotonin, which was their primary way of boosting mood (though they also affect other receptors, leading to notable anticholinergic and sedating side effects). Amitriptyline is a classic example of a tricyclic antidepressant, so it fits this category. The other drugs listed are not TCAs: fluoxetine and sertraline are selective serotonin reuptake inhibitors, and venlafaxine is a serotonin-norepinephrine reuptake inhibitor.